Nanoparticles based on biocompatible and biodegradable polymers, loaded with drugs (NPs) combine these different criteria and thus constitute a performing system in nanotechnology. They can be prepared by emulsion/dispersion polymerization or directly from preformed polymers in
The main objective of this project is based on the preparation of new drug delivery systems, namely NPs, from original polyester-based block copolymers.
First of all, the innovative copolymers, based on poly(ε-caprolactone) (PCL), were synthesized and characterized from a physicochemical point of view. Then, their formulation in NPs loaded with an active principle was studied and the drug release kinetics was evaluated over time.
Through the results obtained, this project contributed to the development of the field of nanoscience and human health care through the simple, reproducible and scalable preparation of controlled drug release systems based on biodegradable polyesters.
Finally, this project allowed the strengthening of collaborative relations with partners from the University of Liege.