During stage I entitled: „Synthesis and characterization of the precursors for the further preparation of N / MPs” several activities were carried out as follows: Act 1.1 – Synthesis and characterization of carboxymethyl chitosan (CMCS) Act 1.2 – Conjugation of CMCS with CGSPGWVRC and indolicidin peptides Act 1.3 – Synthesis and characterization of fluorescein-labeled CMCS
The obtained materials were characterized from several points of view for the correct correlation
of the properties with the synthesis parameters.
During stage II entitled: „Design and synthesis of peptides-functionalized nano / microparticles (2PEP-N / MPs)” several activities were carried out as follows: Act 2.1 – Preparation of nano/microspheres functionalized with peptides Act 2.2 – Preparation of nano/microcapsules functionalized with peptides
Two types of peptide-functionalized particles, nano/microsphere and nano/microcapsules, were
prepared.
During stage III entitled: „Characterization of nano / microparticles functionalized with peptides (2PEP-N / MPs)” several activities were carried out as follows: Act 3.1 – Physico-chemical characterization and correlation of the structure with the properties of
2PEP-N / MPs Act 3.2 – Dexamethasone loading and in vitro release studies
During stage IV entitled: „Evaluation of the biomaterial properties of the 2PEP-N/MPs” several
activities were carried out as follows: Act 4.1 Enzymatic biodegradability studies Act 4.2 In vitro evaluation of 2PEP-N/MPs interaction with blood components Act 4.3 Protein adsorption studies Act 4.4 Bioadhesion tests Act 4.5 Optimization of the preparation process of 2PEP-N/MPs
